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class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022contributors\u0022\u003E\u003Col class=\u0022contributor-list\u0022 id=\u0022contrib-group-1\u0022\u003E\u003Cli class=\u0022contributor\u0022 id=\u0022contrib-1\u0022\u003E\u003Cspan class=\u0022name\u0022\u003EDavid F Mobley\u003C\/span\u003E\u003Ca id=\u0022xref-aff-1-1\u0022 class=\u0022xref-aff\u0022 href=\u0022#aff-1\u0022\u003E1\u003C\/a\u003E, \u003C\/li\u003E\u003Cli class=\u0022contributor\u0022 id=\u0022contrib-2\u0022\u003E\u003Cspan class=\u0022name\u0022\u003EMohit Khera\u003C\/span\u003E\u003Ca id=\u0022xref-aff-2-1\u0022 class=\u0022xref-aff\u0022 href=\u0022#aff-2\u0022\u003E2\u003C\/a\u003E, \u003C\/li\u003E\u003Cli class=\u0022last\u0022 id=\u0022contrib-3\u0022\u003E\u003Cspan class=\u0022name\u0022\u003ENeil Baum\u003C\/span\u003E\u003Ca id=\u0022xref-aff-3-1\u0022 class=\u0022xref-aff\u0022 href=\u0022#aff-3\u0022\u003E3\u003C\/a\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003Col class=\u0022affiliation-list\u0022\u003E\u003Cli class=\u0022aff\u0022\u003E\u003Ca id=\u0022aff-1\u0022 name=\u0022aff-1\u0022\u003E\u003C\/a\u003E\u003Caddress\u003E\n\u003Csup\u003E1\u003C\/sup\u003E\n\u003Cspan class=\u0022institution\u0022\u003EDepartment of Urology\u003C\/span\u003E, \u003Cspan class=\u0022institution\u0022\u003EWeill-Cornell Medicine\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003EHouston\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003ETexas\u003C\/span\u003E, USA\n\u003C\/address\u003E\u003C\/li\u003E\u003Cli class=\u0022aff\u0022\u003E\u003Ca id=\u0022aff-2\u0022 name=\u0022aff-2\u0022\u003E\u003C\/a\u003E\u003Caddress\u003E\n\u003Csup\u003E2\u003C\/sup\u003E\n\u003Cspan class=\u0022institution\u0022\u003EDepartment of Urology\u003C\/span\u003E, \u003Cspan class=\u0022institution\u0022\u003EBaylor College of Medicine\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003EHouston\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003ETexas\u003C\/span\u003E, USA\n\u003C\/address\u003E\u003C\/li\u003E\u003Cli class=\u0022aff\u0022\u003E\u003Ca id=\u0022aff-3\u0022 name=\u0022aff-3\u0022\u003E\u003C\/a\u003E\u003Caddress\u003E\n\u003Csup\u003E3\u003C\/sup\u003E\n\u003Cspan class=\u0022institution\u0022\u003EDepartment of Urology\u003C\/span\u003E, \u003Cspan class=\u0022institution\u0022\u003ETulane Medical School\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003ENew Orleans\u003C\/span\u003E, \u003Cspan class=\u0022addr-line\u0022\u003ELouisiana\u003C\/span\u003E, USA\n\u003C\/address\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003Col class=\u0022corresp-list\u0022\u003E\u003Cli class=\u0022corresp\u0022 id=\u0022corresp-1\u0022\u003E\u003Cspan class=\u0022corresp-label\u0022\u003ECorrespondence to\u003C\/span\u003E\n Dr\u00a0David F\u00a0Mobley, Department of Urology, Weill-Cornell Medicine, 18300 Katy Fwy, Ste 325, Houston 77094, TX, USA; \u003Cspan class=\u0022em-link\u0022\u003E\u003Cspan class=\u0022em-addr\u0022\u003Emobleyresearch{at}gmail.com\u003C\/span\u003E\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n \n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article abstract-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003EAbstract\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EErectile dysfunction (ED) is one of the most common conditions affecting middle-aged and older men. Nearly every primary care physician, internist and geriatrician will be called upon to manage this condition or to make referrals to urologists, endocrinologists and cardiologists who will assist in the treatment of ED. This article will briefly discuss the diagnosis and management of ED. In addition, emerging concepts in ED management will be discussed, such as the use of testosterone to treat ED, the role of the endothelium in men with ED and treating the partner of the man with ED. Finally, future potential therapies for ED will be discussed.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Eerectile dysfunction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eendothelial dysfunction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Etestosterone\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Etestosterone deficiency\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eandrogen deficiency\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Etestosterone replacement\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiovascular disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Estem cells\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Egene therapy\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/93\/1105\/679.full\u0022 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class=\u0022pane-content\u0022\u003E\n \u003Cp\u003E\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1136\/postgradmedj-2016-134073\u0022 target=\u0022_new\u0022\u003Ehttp:\/\/dx.doi.org\/10.1136\/postgradmedj-2016-134073\u003C\/a\u003E\u003C\/p\u003E\n \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022 \u003E\n \n \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/postgradmedj-2016-134073\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-bmjj-jumplinks\u0022 \u003E\n \n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cdiv class=\u0022highwire-list-wrapper\u0022\u003E\u003Cdiv class=\u0022highwire-list\u0022\u003E\u003Cul\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n \n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/erectile-dysfunction\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-erectile-dysfunction\u0022 rel=\u0022nofollow\u0022\u003Eerectile dysfunction\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/endothelial-dysfunction\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-endothelial-dysfunction\u0022 rel=\u0022nofollow\u0022\u003Eendothelial dysfunction\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/testosterone\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-testosterone\u0022 rel=\u0022nofollow\u0022\u003Etestosterone\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/testosterone-deficiency\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-testosterone-deficiency\u0022 rel=\u0022nofollow\u0022\u003Etestosterone deficiency\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/androgen-deficiency\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-androgen-deficiency\u0022 rel=\u0022nofollow\u0022\u003Eandrogen deficiency\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/testosterone-replacement\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-testosterone-replacement\u0022 rel=\u0022nofollow\u0022\u003Etestosterone replacement\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/cardiovascular-disease\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-cardiovascular-disease\u0022 rel=\u0022nofollow\u0022\u003Ecardiovascular disease\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/stem-cells\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-stem-cells\u0022 rel=\u0022nofollow\u0022\u003Estem cells\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/gene-therapy\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-gene-therapy\u0022 rel=\u0022nofollow\u0022\u003Egene therapy\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section intro\u0022 id=\u0022sec-1\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EIntroduction\u003C\/h2\u003E\u003Cp id=\u0022p-2\u0022\u003ENearly every primary care physician, internist and geriatrician now understand that many older men retain an interest in sexual activity as they age. Some primary care physicians think that sexual potency in older men is the norm, and that if it is lacking, it is \u2018all in the head.\u2019 This viewpoint has not been supported by current literature. The Massachusetts Male Aging Study (MMAS) found that 52% of men between 40 and 70 years old reported having some form of erectile dysfunction (ED).\u003Ca id=\u0022xref-ref-1-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-1\u0022\u003E1\u003C\/a\u003E The reality is that ED is a natural part of ageing and that the prevalence increases with age. In the MMAS, they found that roughly 50% of men at 50 years old, 60% of men at 60 years old and 70% of men at 70 years old had ED. Thus, nearly all men who live long enough should develop ED. The myths that surround the problems of impotence or ED confound the attempts of patients to receive treatment and the attempts of physicians to help them.\u003Ca id=\u0022xref-ref-1-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-1\u0022\u003E1\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EMany factors can contribute to sexual dysfunction in older men, including physical and psychological conditions, comorbidities and the medications used to treat them. Aspects of an ageing man\u2019s lifestyle and behaviour and androgen deficiency, most often decreasing testosterone levels, may affect sexual function as well. A study of men between the ages of 30 and 79 years showed that 24% had testosterone levels below 300\u2009ng\/dL and 5.6% had symptomatic androgen deficiency.\u003Ca id=\u0022xref-ref-2-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-2\u0022\u003E2\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe percentage of men who engage in some form of sexual activity decreases from 73% for men aged 57\u201364 years to 26% for men aged 75\u201385 years.\u003Ca id=\u0022xref-ref-3-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E For some men, this constitutes a problem, but for others it does not. The aetiology for this decline in sexual activity is multifactorial and is in part due to the fact that most of the female partners undergo menopause at 52 years of age with a significant decline in their libido and desire to engage in sexual activity. A study by Lindau and colleagues\u003Ca id=\u0022xref-ref-3-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E that examined sexuality in older Americans showed that 50% of the men in a probability sample of more than 3000 US adults reported at least one bothersome sexual problem and 33% had at least two such problems.\u003Ca id=\u0022xref-ref-3-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E This article will review the normal changes that occur with ageing, factors that influence these changes, individual variations and perspectives, and the available treatment options for ED and androgen deficiency.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-2\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EBrief history of the treatment of ED\u003C\/h2\u003E\u003Cp id=\u0022p-5\u0022\u003EImpotence treatments were discussed in the oldest Chinese text, The Yellow Emperor\u2019s Classic of Internal Medicine, which describes traditional Chinese medicine during the time of the Yellow Emperor\u2019s rule which ended around 2600 BC. One of the treatments for impotence discussed is a potion with 22 ingredients.\u003Ca id=\u0022xref-ref-4-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-4\u0022\u003E4\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ENearly 1000 years later, the Egyptian Papyrus Ebers, a medical Egyptian document dated 1600 BC, describes a cure for impotence in which baby crocodile hearts were mixed with wood oil and applied topically to the penis.\u003Ca id=\u0022xref-ref-4-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-4\u0022\u003E4\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EIn 1973, Dr Brantley Scott from Baylor College of Medicine reported on the implantable inflatable prosthesis that urologists still use today.\u003Ca id=\u0022xref-ref-5-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-5\u0022\u003E5\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe major breakthrough occurred in 1998 when sildenafil became the first oral drug to be approved to treat ED.\u003Ca id=\u0022xref-ref-4-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-4\u0022\u003E4\u003C\/a\u003E This was followed by the use of tadalafil and vardenafil as similar phosphodiesterase-5 inhibitor oral medications for treating ED in 2003.\u003Ca id=\u0022xref-ref-4-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-4\u0022\u003E4\u003C\/a\u003E\n\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-3\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EOverview of physiological changes and other risk factors\u003C\/h2\u003E\u003Cp id=\u0022p-9\u0022\u003EAs with most other organ system in the human body, changes and loss of function is normal consequence of the ageing process. This is also true of the endocrine system, specifically the levels of testosterone production from the Leydig cells of the testicle. Accompanying the decrease in testosterone is a decrease in erections which also has a component in decrease in the blood supply to the penis making erection not as frequent and not as rigid compared with a young man\u2019s erectile function. Although these changes are in itself not life threatening, they can impact a man\u2019s relationship with his partner, and also ED may be a harbinger of other undiagnosed conditions such as coronary artery disease (CAD), hypercholesterolaemia or diabetes mellitus.\u003Ca id=\u0022xref-ref-6-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-6\u0022\u003E6\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EED is defined as the inability to achieve a full erection or the inability to maintain an erection adequate for sexual intimacy. Other types of sexual dysfunction such as premature ejaculation and low libido may occur; however, the most common and disruptive problem in men is ED. Although most men will experience periodic episodes of ED, these episodes tend to become more frequent with advancing age.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EMedical conditions, such as hypertension, diabetes mellitus, and cardiovascular disease (CVD), and psychological conditions, such as depression and anxiety, also contribute to sexual dysfunction in middle-aged or elderly men. CVD and hypertension cause a narrowing and hardening of the arteries, leading to reduced blood flow to the corporal bodies, which is essential for achieving an erection. Diabetes is a common aetiology of sexual dysfunction, because it can affect both the blood vessels and the nerves that supply the penis. Men with diabetes are four times more likely to experience ED, and on average, experience ED 15 years earlier than men without diabetes.\u003Ca id=\u0022xref-ref-7-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-7\u0022\u003E7\u003C\/a\u003E Obesity is also correlated to the development of several types of dysfunction, including a decrease in sex drive and an increase in episodes of ED.\u003Ca id=\u0022xref-ref-8-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-8\u0022\u003E8\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-12\u0022\u003EThere are hundreds of medications that have the side effect of ED and\/or decreased libido. Examples of drugs implicated as a cause of ED include hydrochlorothiazides and beta-blocking agents. Medications used to treat depression, particularly the SSRIs such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Prozac Weekly, Sarafem), fluvoxamine (Luvox, Luvox CR), paroxetine (Paxil, Paxil CR, Pexeva) and sertraline (Zoloft), may also contribute to ED.\u003Ca id=\u0022xref-ref-9-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-9\u0022\u003E9\u003C\/a\u003E Bupropion (Wellbutrin) which has a predominant effect on blocking the reuptake of dopamine is an antidepressant with lower incidence of ED.\u003Ca id=\u0022xref-ref-10-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-10\u0022\u003E10\u003C\/a\u003E The side effects of 5ARIs occurring in fewer than 5% of patients can include gynaecomastia, ED, loss of libido and ejaculatory dysfunction.\u003Ca id=\u0022xref-ref-11-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-11\u0022\u003E11\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-13\u0022\u003EMen being treated for prostate cancer with treatments such as radical prostatectomy, radiation therapy or the use of Lutenizing hormone-releasing hormone\u00a0(LHRH) agonists and antagonists can expect that ED may accompany these treatments.\u003Ca id=\u0022xref-ref-12-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-12\u0022\u003E12\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-14\u0022\u003ESmoking, excessive use of alcohol and illicit drugs are also associated with ED.\u003Ca id=\u0022xref-ref-13-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-13\u0022\u003E13\u003C\/a\u003E A study in 2005 suggests that ED is not only more likely among men who smoked compared with those who never did, but that in younger men with ED, cigarette smoking is very likely the cause of their impotence.\u003Ca id=\u0022xref-ref-14-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-14\u0022\u003E14 15\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003EAlso, it is important to remember that there are psychogenic issues such as performance-related issues, traumatic past experiences, relationship problems, anxiety, depression and stress that can certainly cause or be considered a comorbid condition contributing to ED.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EBullet point: Ageing and comorbidities as well as polypharmacy factor greatly influence the development of ED.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-4\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ERole of the endothelium in ED\u003C\/h2\u003E\u003Cp id=\u0022p-17\u0022\u003EThe role of the endothelium in ED has been noted for a number of years and the overlapping of ED and other conditions, especially coronary heart disease, CVD, affecting endothelial function\/dysfunction, is clearly present. The endothelial cell is now known to affect vascular tone and impact the process of atherosclerosis, and impacting ED, CVD and peripheral vascular disease.\u003Ca id=\u0022xref-ref-16-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-16\u0022\u003E16\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-18\u0022\u003EThe role of the endothelium in erectile function became clearer with the observation that the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil, enhanced erectile function. Erection occurs with the release of nitric oxide (NO) from the vascular endothelial cells.\u003Ca id=\u0022xref-ref-17-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-17\u0022\u003E17\u003C\/a\u003E The reduction in endothelial cell production of NO results in the negative impact on the smooth muscles in the corporal bodies and results in less relaxation of the smooth muscle cells with decrease in blood supply and resulting ED. A similar phenomenon is well known to impact the coronary arterial system resulting in CVD.\u003C\/p\u003E\u003Cp id=\u0022p-19\u0022\u003EIt is important to understand that ED is frequently, if not usually, directly related to endothelial dysfunction, and that the release of NO by the vasculature of the penile arteries is directly related to the function of intact, healthy endothelium. In the face of endothelial dysfunction, the process of erection fails to occur in a normal fashion.\u003Ca id=\u0022xref-ref-16-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-16\u0022\u003E16\u003C\/a\u003E\n\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-5\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EThe association of ED, CVD and endothelial dysfunction\u003C\/h2\u003E\u003Cp id=\u0022p-20\u0022\u003EThe pathogenesis of organic ED is related to dysfunction of the endothelium. Endothelial cells can become injured through a variety of mechanisms, most of which cause oxidative stress on the tissues. Many of these causes of oxidative stress are related to lifestyle issues which lead to hypertension, diabetes and dyslipidaemia (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003Efigure 1\u003C\/a\u003E). Endothelial cell dysfunction results in reduction of endothelium-dependent vasorelaxation as well as increased adhesion of leukocytes to the endothelium. Endothelial cell injury then leads to a variety of sequelae, including ED, other types of vasoconstriction, atherosclerosis and thrombus formation.\u003Ca id=\u0022xref-ref-18-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-18\u0022\u003E18\u003C\/a\u003E\n\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Link between oxidative stress, endothelial dysfunction and ED. CVD, cardiovascular disease; ED, erectile dysfunction.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-759591078\u0022 data-figure-caption=\u0022\u0026lt;div class=\u0026quot;highwire-markup\u0026quot;\u0026gt;Link between oxidative stress, endothelial dysfunction and ED. CVD, cardiovascular disease; ED, erectile dysfunction.\u0026lt;\/div\u0026gt;\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 1\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F1.medium.gif\u0022 width=\u0022440\u0022 height=\u0022330\u0022\/\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 1\u0022 src=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F1.medium.gif\u0022 width=\u0022440\u0022 height=\u0022330\u0022\/\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/171040\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1\u003C\/span\u003E \u003Cp id=\u0022p-21\u0022 class=\u0022first-child\u0022\u003ELink between oxidative stress, endothelial dysfunction and ED. CVD, cardiovascular disease; ED, erectile dysfunction.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-22\u0022\u003EThe association of CVD and ED was noted in 1997 as one analysed the results of the MMAS. In this landmark study, 1709 men aged 40\u201370 years were enrolled between 1987 and 1989. A follow-up some 10 years later revealed a striking relationship between ED and CVD. In this study, it became clear that the risk factors for ED were very similar to those of CVD, such as diabetes mellitus, smoking and dyslipidaemia.\u003Ca id=\u0022xref-ref-18-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-18\u0022\u003E18\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-23\u0022\u003ESince endothelial dysfunction, CVD and ED are closely associated in epidemiological studies, the question for clinicians is whether to recommend the man presenting with ED undergo a cardiovascular (CV) evaluation. Clearly, based on numerous studies, ED can be considered at least a \u2018marker\u2019 for possible further vascular disease or CVD.\u003Ca id=\u0022xref-ref-15-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-15\u0022\u003E15\u003C\/a\u003E In their report, Vlachopoulos and coworkers make the point that the man presenting with ED, the clinician, is offered an opportunity to attempt to improve the health of the man by addressing lifestyle modification, and consider further vascular evaluation owing to the clear relationship between endothelial dysfunction, ED and CVD.\u003Ca id=\u0022xref-ref-19-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-19\u0022\u003E19\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-24\u0022\u003EWatts and coworkers, in their review article, make several points about this ED\/CAD nexus. Endothelial dysfunction is present in both CVD and ED, and is linked through the NO mechanism. The authors note that PDE5 inhibitors improve endothelial function and have a salutary effect on both CVD and ED. Both ED and cardiac disease respond to modifications in lifestyle as well as pharmacologic manipulation. These authors also report that the presence of ED gives the clinician an opportunity to assess CVD and prevention as well.\u003Ca id=\u0022xref-ref-20-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-25\u0022\u003EDue to the fact that ED and CVD share many of the same risk factors, it is not surprising that there is a high incidence of ED in men who present with CVD. A study by Montorsi \u003Cem\u003Eet al\u003C\/em\u003E found that ED was present in roughly 50% of patients with acute chest pain and confirmed CAD on angiography.\u003Ca id=\u0022xref-ref-21-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-21\u0022\u003E21\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-26\u0022\u003EIn this study, ED proceeded CVD in almost 70% of cases. Similarly, many men with ED have been found to have pre-existing CVD. A study by Vlachopoulos \u003Cem\u003Eet al\u003C\/em\u003E evaluated the incidence of asymptomatic CVD in 50 men with ED.\u003Ca id=\u0022xref-ref-22-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E These authors found that 19% of men with ED had asymptomatic CVD. Similarly, Mulhall and colleagues found that 20% of men presenting with ED and vascular insufficiency on penile duplex had asymptomatic CVD.\u003Ca id=\u0022xref-ref-23-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-23\u0022\u003E23\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-27\u0022\u003EThese findings suggest that patients who present with ED and CV risk factors should be evaluated for silent CVD and should undergo a thorough CV evaluation.\u003C\/p\u003E\u003Cp id=\u0022p-28\u0022\u003EMen with new onset ED and no signs or symptoms of CVD are at increased risk for experiencing a CV event in the subsequent 3\u20135 years.\u003Ca id=\u0022xref-ref-24-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-24\u0022\u003E24\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-29\u0022\u003EMen in their 40s with ED have a 50-fold increased risk of CVD and men in their 20s and 30s have a sevenfold increased CV risk.\u003Ca id=\u0022xref-ref-25-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-25\u0022\u003E25\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-30\u0022\u003EA meta-analysis of 36\u2009744 men with ED in 12 prospective cohort studies found that the presence of ED significantly increased the risk of CVD, CAD, stroke and all-cause mortality, and the presence of ED was an independent risk factor for CVD. Ponholzer \u003Cem\u003Eet al\u003C\/em\u003E found that men with moderate to severe ED had a 65% increased relative risk for developing symptomatic CAD compared with men who did not have ED.\u003Ca id=\u0022xref-ref-26-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-31\u0022\u003EThe Prostate Cancer Prevention Trial was a landmark study by Thompson \u003Cem\u003Eet al\u003C\/em\u003E that prospectively assessed the time to developing CVD after the diagnosis of ED. There were 4247 men with no ED at study entry; 2420 developed incident ED (defined as the first report of ED of any grade) over 5 years. Those men that developed ED had a 1.45-fold higher probability of experiencing a CV event compared with men who did not develop ED.\u003Ca id=\u0022xref-ref-27-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-27\u0022\u003E27\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-32\u0022\u003EThe severity of ED has been correlated with the extent of CVD. Banks \u003Cem\u003Eet al\u003C\/em\u003E reported that the risk of future CV events increased progressively according to ED severity.\u003Ca id=\u0022xref-ref-28-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-28\u0022\u003E28\u003C\/a\u003E This was shown in both men with and without known CVD at baseline and after controlling for confounders. Solomon and colleagues found an inverse correlation between international index of erectile function\u00a0(IIEF) scores and plaque burden seen on coronary angiography.\u003Ca id=\u0022xref-ref-29-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-29\u0022\u003E29\u003C\/a\u003E In addition, Yaman \u003Cem\u003Eet al\u003C\/em\u003E demonstrated a significant correlation between ED severity on IIEF questionnaires and coronary artery calcification.\u003Ca id=\u0022xref-ref-30-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-30\u0022\u003E30\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-33\u0022\u003EFinally, Dr Montorsi \u003Cem\u003Eet al\u003C\/em\u003E found that severe ED was more common in patients with multivessel coronary involvement as compared with those with single-vessel disease (31% vs 12.5%; p\u0026lt;0.01). They also found a significant inverse relationship between the extent of CVD and IIEF scores.\u003Ca id=\u0022xref-ref-31-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-31\u0022\u003E31\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-34\u0022\u003ENormal erectile function depends on the release of NO and endothelial-dependent vasodilation of the penile arteries. The \u2018artery size\u2019 hypothesis, first described by Dr Montorsi, offers an explanation why men are more likely to develop ED before a myocardial infacrtion. It is believed that atherosclerosis affects all vascular beds equally but smaller arteries are more likely to become occluded than larger arteries.\u003Ca id=\u0022xref-ref-31-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-31\u0022\u003E31 32\u003C\/a\u003E The penile arteries are 1\u20132\u2009mm while the coronary arteries are 3\u20134\u2009mm. Thus, the same degree of endothelial dysfunction and atherosclerosis is more likely to occlude blood flow in the penile arteries compared with the coronary arteries. The penile arteries therefore serve as a sensitive indicator for subsequent CVD. This theory is supported by the fact that ED occurs approximately 3 years prior to cardiac symptoms in virtually all patients with chronic coronary syndrome whereas patients with acute coronary syndrome have a much lower prevalence of sexual dysfunction.\u003Ca id=\u0022xref-ref-32-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-32\u0022\u003E32\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-35\u0022\u003EBullet point: The relationship between the risk factors for CVD and ED are intimately interwoven, one with the other. Clinicians need to factor this in when counselling the man with ED.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-6\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ETestosterone and erectile function\u003C\/h2\u003E\u003Cp id=\u0022p-36\u0022\u003EAmong the phenomena in the ageing man are a decrease in erectile function and testosterone levels. Add to these, increased risk for CVD, muscle wasting, decrease in bone density and libido, with all of these factors having an interplay with testosterone metabolism.\u003Ca id=\u0022xref-ref-33-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-33\u0022\u003E33\u003C\/a\u003E Androgens play a key role in maintaining erectile function through four main mechanisms. Androgen deprivation has been shown to result in impairment of NO synthase release, altered PDE5 expression and activity, impaired cavernosal nerve function, and contribution to veno-occlusive disease in the penis.\u003Ca id=\u0022xref-ref-34-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-34\u0022\u003E34\u003C\/a\u003E The role of testosterone replacement therapy (TRT) as a potential to improve erectile function in the man with ED remains an issue for patient and physicians who are comfortable treating androgen deficiency which include primary care physicians and specialists. Androgens are known to have a significant impact on the function of the smooth musculature within the corpus spongiosum.\u003Ca id=\u0022xref-ref-35-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-35\u0022\u003E35\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-37\u0022\u003EThe observation that TRT enhances the efficacy of PDE5 inhibitors in hypogonadal men taking these therapies with suboptimal response to the PDE5 inhibitors alone has been reported.\u003Ca id=\u0022xref-ref-33-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-33\u0022\u003E33\u003C\/a\u003E In addition, investigators have demonstrated that TRT in hypogonadal men can improve erectile function even without the benefit of PDE5 inhibitors.\u003Ca id=\u0022xref-ref-33-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-33\u0022\u003E33\u003C\/a\u003E In addition, guidelines for managing ED in hypogonadal men by the European Association of Urology recommend controlling the man to a eugonadal state prior to initiation of PDE5 inhibitor therapy.\u003Ca id=\u0022xref-ref-36-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-36\u0022\u003E36\u003C\/a\u003E Testosterone measurement consists of a serum specimen which should be ideally obtained in the morning because of the normal diurnal variation of testosterone which is at its peak in the morning. Since TRT is relatively safe, and men can potentially see an improvement in erectile function, it seems prudent to consider this issue when presented with a patient suffering from ED.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-7\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ESafety of TRT\u003C\/h2\u003E\u003Cp id=\u0022p-38\u0022\u003ERecently, the US Food and Drug Administration (FDA) has issued a safety announcement regarding TRT. In part it reads \u2018The benefit and safety of these medications have not been established. We are also requiring these manufacturers to add information to the labeling about a possible increased risk of heart attacks and strokes in patients taking testosterone.\u2019\u003Ca id=\u0022xref-ref-37-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-37\u0022\u003E37\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-39\u0022\u003EIn their extensive review, Bassil and coworkers summarise the benefits and risks, with benefits such as improvement of sexual function, bone density, muscle strength, cognition and overall improvement in quality of life. Among the risks that have been suggested include erythrocytosis, liver toxicity, worsening of sleep apnoea and cardiac function, possibly increasing symptoms of benign prostatic hyperplasia (BPH). They also note that although a possibility of stimulation of prostate cancer has been hypothesised, no scientific or clinical evidence exists to this possible risk.\u003Ca id=\u0022xref-ref-38-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-38\u0022\u003E38\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-40\u0022\u003EErythrocytosis has been noted in men on TRT, and should be monitored every 6\u201312 months depending upon the patients\u2019 response to changes in haematocrit levels. For mild elevations, the dosage of testosterone can be decreased or the interval of using the medication can be increased. With the haematocrit greater than 50%, decisions to temporarily discontinue the medication or periodic phlebotomy may be indicated.\u003Ca id=\u0022xref-ref-38-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-38\u0022\u003E38\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-41\u0022\u003ELiver toxicity has generally been associated with oral forms of TRT, but does not appear to be a risk in injection or transdermal therapy.\u003Ca id=\u0022xref-ref-39-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-39\u0022\u003E39\u003C\/a\u003E In patients with marked obstructive sleep apnoea or untreated severe congestive heart failure, these issues should be resolved before initiating TRT.\u003Ca id=\u0022xref-ref-37-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-37\u0022\u003E37\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-42\u0022\u003EClinicians should be aware of these possible detrimental effects of TRT and the possible contraindications, and to prescribe and monitor in an appropriate manner, which may vary from patient to patient.\u003C\/p\u003E\u003Cp id=\u0022p-43\u0022\u003EBullet point: In men with ED, assessing androgen status is a simple evaluation, and therapy when indicated can be beneficial, and in most men, safe.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-8\u0022\u003E\u003Ch2 class=\u0022\u0022\u003ECurrent treatment options\u003C\/h2\u003E\u003Cp id=\u0022p-44\u0022\u003EAs is true in so many medical conditions, lifestyle modifications, considered first-line therapy, can have a salutary effect in ED management, and men should be encouraged to make the necessary changes to the benefit of their sexual function and to their overall health as well. Despite the benefits of behaviour modification, men presenting with ED want the physician to help with measures that can have an immediate impact.\u003C\/p\u003E\u003Cp id=\u0022p-45\u0022\u003EThe options for management beyond behaviour modification include TRT, PDE5 inhibitors, intracavernosal injection therapy, vacuum constriction devices (VCDs), intraurethral prostaglandin suppositories and surgical placement of a penile prosthesis.\u003Ca id=\u0022xref-ref-40-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-40\u0022\u003E40\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-46\u0022\u003EPDE5 inhibitors, the primary second-line therapy, have been the mainstay of ED treatment since the release of sildenafil (Viagra) in 1998, with the subsequent development of many others, and still more in the development stage. These medications do improve erectile quality for the majority of men, and they work by enhancing blood flow in the corpora cavernosa. These medications are generally used on demand and need to be taken about an hour before sexual intimacy. Tadalafil (Cialis) is longer acting and does come in a daily preparation potentially eliminating the \u2018on-demand\u2019 need. The daily dosing of tadalafil, 2.5\u20135\u2009mg\\day, has also been approved by the FDA for treatment of symptoms of BPH.\u003Ca id=\u0022xref-ref-41-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-41\u0022\u003E41\u003C\/a\u003E PDE5 inhibitors are contraindicated in men taking nitrates, but otherwise PDE5 inhibitors are very safe and effective. When PDE5 inhibitors are coadministered with nitrates, pronounced systemic vasodilation and severe hypotension are possible. Many patients with ED are elderly and have the same risk factors as patients with CAD, so these drug combinations are commonly considered or encountered in clinical practice.\u003Ca id=\u0022xref-ref-42-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-42\u0022\u003E42\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-47\u0022\u003EIt is important for clinicians prescribing these drugs to make the patient aware of the action of the drugs especially the fact that they do not result in an immediate erection, and that they do not cause an erection without sexual stimulation. There is frequently a great expectation when men begin using these drugs and it is wise to temper their enthusiasm and explain they do not work immediately, and may not work every time, but also let the patient know that if these drugs do not work, there are other options.\u003C\/p\u003E\u003Cp id=\u0022p-48\u0022\u003EBesides PDE5 inhibitors and among second-line therapies are VCDs which are clear plastic chambers placed over the penis, tightened against the lower abdomen with a mechanism to create a vacuum inside the chamber. This directs blood into the penis. If an adequate erection occurs inside the chamber, the patient slips a small constriction band off the end of the VCD and onto the base of the penis. An erection beyond 30\u2009min is not recommended. These devices can be a bit cumbersome, but are very safe.\u003Ca id=\u0022xref-ref-40-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-40\u0022\u003E40\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-49\u0022\u003EAnother second-line therapy is the use of alprostadil, either intracavernosal or intraurethral. Two products are available for direct injection, Caverject (Pfizer) or Edex (Actient). A small needle is used to inject the medication into the lateral aspect of the penis through a small-gauge needle.\u003C\/p\u003E\u003Cp id=\u0022p-50\u0022\u003EResponse is dose related and usually occurs within 10\u201315\u2009min, and does not require stimulation. The intraurethral preparation, medicated urethral suppository for erection\u00a0(MUSE), consists of a tiny pellet of drug inserted into the urethral meatus. Response is also dose related, and onset similar to the cavernosal preparations.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-9\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EPsychosexual counselling\u003C\/h2\u003E\u003Cp id=\u0022p-51\u0022\u003EPsychosexual counselling, or sex therapy, is an appropriate recommendation especially for men who are experiencing discord with their partner especially if the conflict is related to the man\u2019s ED. Counselling usually consists of 5\u201320 sessions with counsellor. It is our recommendation that referral doctors treating men with ED make a referral to a psychotherapist or sex therapist who is certified by AASECT (American Association of Sexuality Educators, Counselors and Therapists) of certified sexuality educator.\u003Ca id=\u0022xref-ref-43-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-43\u0022\u003E43\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-52\u0022\u003EStudies have shown that for men with stress-related ED, when the partner is involved in the therapy, the problem is resolved 50%\u201370% of the time. When the man must go through counselling alone, the results are less successful. Psychosexual counselling is unlikely to be effective if a man drops out of treatment after just one or two sessions.\u003Ca id=\u0022xref-ref-44-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-44\u0022\u003E44\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-53\u0022\u003EIn patients who either fail to respond to first or second-line therapy, or are not interested in the conservative therapies, penile prosthesis implantation is available. Malleable and rigid implants were available for many years, but in 1973 the world of penile prosthetics took a giant leap forward with the advent of the inflatable penile implant. Most implants done nowadays are of the inflatable variety. Adverse events including malfunction and infection are rare, and patient satisfaction is very high.\u003Ca id=\u0022xref-ref-45-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-45\u0022\u003E45\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-54\u0022\u003EFor an algorithm to facilitate evaluation and treatment of patients with ED, see \u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003Efigure 2\u003C\/a\u003E.\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Algorithm for evaluating and managing the patient with ED. CV, cardiovascular; CVD, cardiovascular disease; ED, erectile dysfunction.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-759591078\u0022 data-figure-caption=\u0022\u0026lt;div class=\u0026quot;highwire-markup\u0026quot;\u0026gt;Algorithm for evaluating and managing the patient with ED. CV, cardiovascular; CVD, cardiovascular disease; ED, erectile dysfunction.\u0026lt;\/div\u0026gt;\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 2\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F2.medium.gif\u0022 width=\u0022406\u0022 height=\u0022440\u0022\/\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 2\u0022 src=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F2.medium.gif\u0022 width=\u0022406\u0022 height=\u0022440\u0022\/\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/postgradmedj\/93\/1105\/679\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/171032\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2\u003C\/span\u003E \u003Cp id=\u0022p-55\u0022 class=\u0022first-child\u0022\u003EAlgorithm for evaluating and managing the patient with ED. CV, cardiovascular; CVD, cardiovascular disease; ED, erectile dysfunction.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-10\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EFuture therapies\u003C\/h2\u003E\u003Cp id=\u0022p-56\u0022\u003EOn the horizon is gene therapy that would deliver genes that produce products or proteins that may not be functioning properly in the penile tissue of men with ED. Replacement of these proteins may result in improvement in erectile function. Experimental animal models have demonstrated improvement in erectile function with gene therapy. Human studies may also demonstrate success with this therapy. Gene therapy may take a long time for regulatory approval and public acceptance.\u003C\/p\u003E\u003Cp id=\u0022p-57\u0022\u003EThe first stem cell study for the treatment of ED was published in 2004. This study used embryonic stem cells to treat ED. At this time, there is a total of 36 published basic studies assessing stem cell therapy for ED, with two clinical trials. The mechanism of action of stem cells is to generate angiogenesis with subsequent increase in cavernosal smooth muscle cells within the corporal bodies.\u003Ca id=\u0022xref-ref-46-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-46\u0022\u003E46\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-58\u0022\u003EAnother potential new treatment consists of penile low-intensity shock wave lithotripsy. This consists of 1500 shocks twice a week for 3\u20136 weeks. The purpose is to stimulate neovascularisation to the corporal bodies with improvement in penile blood flow and endothelial function. The use of low-intensity shock wave lithotripsy may convert PDE5 inhibitor non-responders to responders.\u003Ca id=\u0022xref-ref-47-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-47\u0022\u003E47\u003C\/a\u003E\n\u003C\/p\u003E\u003Cp id=\u0022p-59\u0022\u003EFinally, there are NO-releasing polymers that are capable of delivering NO in a pharmacologically useful way. Such compounds include compounds that release NO upon being metabolised and compounds that release NO spontaneously in aqueous solution. Initial animal studies suggest that cavernosal injections of NO polymers can significantly improve erectile function.\u003Ca id=\u0022xref-ref-48-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-48\u0022\u003E48\u003C\/a\u003E\n\u003C\/p\u003E\u003Cdiv class=\u0022boxed-text\u0022 id=\u0022boxed-text-1\u0022\u003E\u003Ch3\u003ECurrent research\u00a0questions\u003C\/h3\u003E\u003Cul class=\u0022list-unord \u0022 id=\u0022list-1\u0022\u003E\u003Cli id=\u0022list-item-1\u0022\u003E\u003Cp id=\u0022p-60\u0022\u003EMany areas in the field of ED remain ripe for further investigation:\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-2\u0022\u003E\u003Cp id=\u0022p-61\u0022\u003ECan we develop a simple yet accurate method to distinguish organic from psychogenic ED?\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-3\u0022\u003E\u003Cp id=\u0022p-62\u0022\u003EWhat are truly the norms for testosterone levels in men and could we better determine which might actually benefit, and thus, should receive TRT?\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-4\u0022\u003E\u003Cp id=\u0022p-63\u0022\u003EWhat is the future of stem-cell therapy in the treatment of men with ED\u003C\/p\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022boxed-text\u0022 id=\u0022boxed-text-2\u0022\u003E\u003Ch3\u003EMain\u00a0messages\u003C\/h3\u003E\u003Cul class=\u0022list-unord \u0022 id=\u0022list-2\u0022\u003E\u003Cli id=\u0022list-item-5\u0022\u003E\u003Cp id=\u0022p-64\u0022\u003EThe risk of developing ED increases with age.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-6\u0022\u003E\u003Cp id=\u0022p-65\u0022\u003ENearly every primary care physician, internist and geriatrician will be treating men with ED.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-7\u0022\u003E\u003Cp id=\u0022p-66\u0022\u003EThe recent shift in the management and evaluation of ED, with primary care physicians replacing urologists in the forefront of ED diagnosis and therapy, has been a welcome and timely change.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-8\u0022\u003E\u003Cp id=\u0022p-67\u0022\u003EIt is likely to improve ED management and benefit a large number of men, particularly in terms of recognising ED as a sentinel of vascular disease.\u003C\/p\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022boxed-text\u0022 id=\u0022boxed-text-3\u0022\u003E\u003Ch3\u003ESelf assessment questions\u003C\/h3\u003E\u003Cp id=\u0022p-68\u0022\u003EPlease answer true and false to the below statements.\u003C\/p\u003E\u003Col class=\u0022list-ord \u0022 id=\u0022list-3\u0022\u003E\u003Cli id=\u0022list-item-9\u0022\u003E\u003Cp id=\u0022p-69\u0022\u003EMen in their 40s with erectile dysfunction (ED) compared with men without a history of ED have an increased risk of developing cardiovascular disease (CVD) in 5 years.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-10\u0022\u003E\u003Cp id=\u0022p-70\u0022\u003EMen presenting with ED should have consideration for a cardiovascular work-up as significant numbers of these men have occult or asymptomatic heart or vascular disease.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-11\u0022\u003E\u003Cp id=\u0022p-71\u0022\u003EEndothelial dysfunction is more common in men with ED than in men with CVD.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-12\u0022\u003E\u003Cp id=\u0022p-72\u0022\u003EThe most likely explanation for men developing ED prior to developing CVD is that the penile arteries are much smaller than the coronary arteries and the smaller penile arteries are likely to be occluded before the coronary arteries are significantly narrowed and become symptomatic.\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-13\u0022\u003E\u003Cp id=\u0022p-73\u0022\u003EAll men receiving testosterone replacement need to have periodic measurement of haemoglobin and haematocrit to monitor for erythrocytosis.\u003C\/p\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003Cdiv class=\u0022boxed-text\u0022 id=\u0022boxed-text-4\u0022\u003E\u003Ch3\u003EAnswers\u003C\/h3\u003E\u003Col class=\u0022list-ord \u0022 id=\u0022list-4\u0022\u003E\u003Cli id=\u0022list-item-14\u0022\u003E\u003Cp id=\u0022p-74\u0022\u003ETrue\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-15\u0022\u003E\u003Cp id=\u0022p-75\u0022\u003ETrue\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-16\u0022\u003E\u003Cp id=\u0022p-76\u0022\u003EFalse (both groups have endothelial dysfunction)\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-17\u0022\u003E\u003Cp id=\u0022p-77\u0022\u003ETrue\u003C\/p\u003E\u003C\/li\u003E\u003Cli id=\u0022list-item-18\u0022\u003E\u003Cp id=\u0022p-78\u0022\u003ETrue\u003C\/p\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section ref-list\u0022 id=\u0022ref-list-1\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EReferences\u003C\/h2\u003E\u003Col class=\u0022cit-list\u0022\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-1-1\u0022 title=\u0022View reference 1 in text\u0022 id=\u0022ref-1\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.1\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFeldman\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGoldstein\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatzichristou\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDG\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EImpotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1994\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E151\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E54\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E61\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DThe%2BJournal%2Bof%2Burology%26rft.stitle%253DJ%2BUrol%26rft.aulast%253DFeldman%26rft.auinit1%253DH.%2BA.%26rft.volume%253D151%26rft.issue%253D1%26rft.spage%253D54%26rft.epage%253D61%26rft.atitle%253DImpotence%2Band%2Bits%2Bmedical%2Band%2Bpsychosocial%2Bcorrelates%253A%2Bresults%2Bof%2Bthe%2BMassachusetts%2BMale%2BAging%2BStudy.%26rft_id%253Dinfo%253Apmid%252F8254833%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=8254833\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=A1994ML65200019\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-2-1\u0022 title=\u0022View reference 2 in text\u0022 id=\u0022ref-2\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.2\u0022 data-doi=\u002210.1210\/jc.2007-1245\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAraujo\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EEsche\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKupelian\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EV\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPrevalence of symptomatic androgen deficiency in men\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Endocrinol Metab\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E92\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E4241\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E7\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1210\/jc.2007-1245\u0022\u003Edoi:10.1210\/jc.2007-1245\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJ%2BClin%2BEndocrinol%2BMetab%26rft_id%253Dinfo%253Adoi%252F10.1210%252Fjc.2007-1245%26rft_id%253Dinfo%253Apmid%252F17698901%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1210\/jc.2007-1245\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17698901\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000250763800026\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-3-1\u0022 title=\u0022View reference 3 in text\u0022 id=\u0022ref-3\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.3\u0022 data-doi=\u002210.1056\/NEJMoa067423\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELindau\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EST\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESchumm\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELaumann\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEO\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EA study of sexuality and health among older adults in the United States\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EN Engl J Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E357\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E762\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E74\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1056\/NEJMoa067423\u0022\u003Edoi:10.1056\/NEJMoa067423\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DLindau%26rft.auinit1%253DS.%2BT.%26rft.volume%253D357%26rft.issue%253D8%26rft.spage%253D762%26rft.epage%253D774%26rft.atitle%253DA%2Bstudy%2Bof%2Bsexuality%2Band%2Bhealth%2Bamong%2Bolder%2Badults%2Bin%2Bthe%2BUnited%2BStates.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa067423%26rft_id%253Dinfo%253Apmid%252F17715410%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1056\/NEJMoa067423\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17715410\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000248906700005\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-4-1\u0022 title=\u0022View reference 4 in text\u0022 id=\u0022ref-4\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.4\u0022 data-doi=\u002210.1046\/j.1464-410X.2002.02911.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShah\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction through the ages\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EBJU Int\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2002\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E90\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E433\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E41\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1046\/j.1464-410X.2002.02911.x\u0022\u003Edoi:10.1046\/j.1464-410X.2002.02911.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DBJU%2Binternational%26rft.stitle%253DBJU%2BInt%26rft.aulast%253DShah%26rft.auinit1%253DJ.%26rft.volume%253D90%26rft.issue%253D4%26rft.spage%253D433%26rft.epage%253D441%26rft.atitle%253DErectile%2Bdysfunction%2Bthrough%2Bthe%2Bages.%26rft_id%253Dinfo%253Adoi%252F10.1046%252Fj.1464-410X.2002.02911.x%26rft_id%253Dinfo%253Apmid%252F12175404%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1046\/j.1464-410X.2002.02911.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=12175404\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000177440100017\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-5-1\u0022 title=\u0022View reference 5 in text\u0022 id=\u0022ref-5\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.5\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMobley\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EEarly history of inflatable penile prosthesis surgery\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAsian J Androl\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2015\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E17\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E225\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E9\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DAsian%2BJ%2BAndrol%26rft.volume%253D17%26rft.spage%253D225%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-6-1\u0022 title=\u0022View reference 6 in text\u0022 id=\u0022ref-6\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.6\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERoumegu\u00e8re\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWespes\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarpentier\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EY\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile Dysfunction is associated with a high prevalence of hyperlipidemia and coronary Heart Disease Risk European Urology\u003C\/span\u003E.\u003Cspan class=\u0022cit-vol\u0022\u003E44\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E355\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E9\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-7-1\u0022 title=\u0022View reference 7 in text\u0022 id=\u0022ref-7\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.7\u0022 data-doi=\u002210.2337\/diacare.19.2.135\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKlein\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKlein\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELee\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKE\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPrevalence of self-reported erectile dysfunction in people with long-term IDDM\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EDiabetes Care\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1996\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E19\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E135\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E41\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2337\/diacare.19.2.135\u0022\u003Edoi:10.2337\/diacare.19.2.135\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DDiabetes%2BCare%26rft.stitle%253DDiabetes%2BCare%26rft.aulast%253DKlein%26rft.auinit1%253DR.%26rft.volume%253D19%26rft.issue%253D2%26rft.spage%253D135%26rft.epage%253D141%26rft.atitle%253DPrevalence%2Bof%2BSelf-Reported%2BErectile%2BDysfunction%2Bin%2BPeople%2BWith%2BLong-Term%2BIDDM%26rft_id%253Dinfo%253Adoi%252F10.2337%252Fdiacare.19.2.135%26rft_id%253Dinfo%253Apmid%252F8718433%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/ijlink\/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NzoiZGlhY2FyZSI7czo1OiJyZXNpZCI7czo4OiIxOS8yLzEzNSI7czo0OiJhdG9tIjtzOjMwOiIvcG9zdGdyYWRtZWRqLzkzLzExMDUvNjc5LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-ijlink\u0022\u003E\u003Cspan\u003E\u003Cspan class=\u0022cit-reflinks-abstract\u0022\u003EAbstract\u003C\/span\u003E\u003Cspan class=\u0022cit-sep cit-reflinks-variant-name-sep\u0022\u003E\/\u003C\/span\u003E\u003Cspan class=\u0022cit-reflinks-full-text\u0022\u003E\u003Cspan class=\u0022free-full-text\u0022\u003EFREE \u003C\/span\u003EFull Text\u003C\/span\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-8-1\u0022 title=\u0022View reference 8 in text\u0022 id=\u0022ref-8\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.8\u0022 data-doi=\u002210.1038\/sj.ijo.0803604\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELarsen\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWagner\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHeitmann\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBL\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESexual function and obesity\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EInt J Obes\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E31\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1189\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E98\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1038\/sj.ijo.0803604\u0022\u003Edoi:10.1038\/sj.ijo.0803604\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DInternational%2Bjournal%2Bof%2Bobesity%26rft.stitle%253DInt%2BJ%2BObes%26rft.aulast%253DSoderberg%26rft.auinit1%253DS.%26rft.volume%253D31%26rft.issue%253D8%26rft.spage%253D1189%26rft.epage%253D1198%26rft.atitle%253DSexual%2Bfunction%2Band%2Bobesity.%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fsj.ijo.0803604%26rft_id%253Dinfo%253Apmid%252F17372616%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1038\/sj.ijo.0803604\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17372616\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000248443100001\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-9-1\u0022 title=\u0022View reference 9 in text\u0022 id=\u0022ref-9\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.9\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcWaine\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EProcci\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWR\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EDrug-induced sexual dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EMed Toxicol Adverse Drug Exp\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1988\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E3\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E289\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E306\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1007\/BF03259941\u0022\u003Edoi:10.1007\/BF03259941\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DMedical%2Btoxicology%26rft.stitle%253DMed%2BToxicol%26rft.aulast%253DMcWaine%26rft.auinit1%253DD.%2BE.%26rft.volume%253D3%26rft.issue%253D4%26rft.spage%253D289%26rft.epage%253D306%26rft.atitle%253DDrug-induced%2Bsexual%2Bdysfunction.%26rft_id%253Dinfo%253Apmid%252F3054427%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=3054427\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-10-1\u0022 title=\u0022View reference 10 in text\u0022 id=\u0022ref-10\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.10\u0022 data-doi=\u002210.1016\/S0149-2918(00)88317-4\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECroft\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESettle\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHouser\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EA placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClin Ther\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1999\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E21\u003C\/span\u003E(\u003Cspan class=\u0022cit-issue\u0022\u003E4\u003C\/span\u003E):\u003Cspan class=\u0022cit-fpage\u0022\u003E643\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E58\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/S0149-2918(00)88317-4\u0022\u003Edoi:10.1016\/S0149-2918(00)88317-4\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DClinical%2Btherapeutics%26rft.stitle%253DClin%2BTher%26rft.aulast%253DCroft%26rft.auinit1%253DH.%26rft.volume%253D21%26rft.issue%253D4%26rft.spage%253D643%26rft.epage%253D658%26rft.atitle%253DA%2Bplacebo-controlled%2Bcomparison%2Bof%2Bthe%2Bantidepressant%2Befficacy%2Band%2Beffects%2Bon%2Bsexual%2Bfunctioning%2Bof%2Bsustained-release%2Bbupropion%2Band%2Bsertraline.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0149-2918%252800%252988317-4%26rft_id%253Dinfo%253Apmid%252F10363731%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/S0149-2918(00)88317-4\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10363731\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000080393000004\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-11-1\u0022 title=\u0022View reference 11 in text\u0022 id=\u0022ref-11\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.11\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJaneway\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBaum\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EManaging the enlarged prostate gland in elderly men\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClinical Geriatrics\u003C\/abbr\u003E \u003Ca href=\u0022http:\/\/www.consultant360.com\/articles\/managing-enlarged-prostate-gland-elderly-men\u0022\u003Ehttp:\/\/www.consultant360.com\/articles\/managing-enlarged-prostate-gland-elderly-men\u003C\/a\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-12-1\u0022 title=\u0022View reference 12 in text\u0022 id=\u0022ref-12\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.12\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKumar\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBarqawi\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECrawford\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EED\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAdverse events associated with hormonal therapy for prostate Cancer\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERev Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E7 Suppl 5\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003ES37\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003ES43\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DRev%2BUrol%26rft.volume%253D75%26rft.spage%253DS37%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-13-1\u0022 title=\u0022View reference 13 in text\u0022 id=\u0022ref-13\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.13\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAksam\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYassin\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESaad\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ETestosterone and erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Andrology\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2008\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E29\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-14-1\u0022 title=\u0022View reference 14 in text\u0022 id=\u0022ref-14\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.14\u0022 data-doi=\u002210.1093\/aje\/kwi052\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGades\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENehra\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJacobson\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAssociation between smoking and erectile dysfunction: a population-based study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAm J Epidemiol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E161\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E346\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E51\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1093\/aje\/kwi052\u0022\u003Edoi:10.1093\/aje\/kwi052\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DAmerican%2BJournal%2Bof%2BEpidemiology%26rft.stitle%253DAm%2BJ%2BEpidemiol%26rft.aulast%253DGades%26rft.auinit1%253DN.%2BM.%26rft.volume%253D161%26rft.issue%253D4%26rft.spage%253D346%26rft.epage%253D351%26rft.atitle%253DAssociation%2Bbetween%2BSmoking%2Band%2BErectile%2BDysfunction%253A%2BA%2BPopulation-based%2BStudy%26rft_id%253Dinfo%253Adoi%252F10.1093%252Faje%252Fkwi052%26rft_id%253Dinfo%253Apmid%252F15692078%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1093\/aje\/kwi052\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=15692078\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000227145500006\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-14-1\u0022 title=\u0022View reference 15 in text\u0022 id=\u0022ref-15\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.15\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMobley\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBaum\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESmoking: it\u2019s impact on urologic conditions\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERev Urology 17\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2015\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-16-1\u0022 title=\u0022View reference 16 in text\u0022 id=\u0022ref-16\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.16\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EStein\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERA\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EEndothelial dysfunction, erectile dysfunction, and coronary heart disease: the pathophysiologic and clinical linkage\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERev Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2003\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E5\u003C\/span\u003E(\u003Cspan class=\u0022cit-issue\u0022\u003ESuppl 7\u003C\/span\u003E):\u003Cspan class=\u0022cit-fpage\u0022\u003ES21\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003ES27\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DRev%2BUrol%26rft.volume%253D5%26rft.spage%253DS21%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-17-1\u0022 title=\u0022View reference 17 in text\u0022 id=\u0022ref-17\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.17\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAndersson\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EStief\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPenile erection and cardiac risk: pathophysiologic and pharmacologic mechanisms\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAm J Cardiol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2000\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E86\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E23\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E6\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/S0002-9149(00)00887-0\u0022\u003Edoi:10.1016\/S0002-9149(00)00887-0\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DAm%2BJ%2BCardiol%26rft.volume%253D86%26rft.spage%253D23%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-18-1\u0022 title=\u0022View reference 18 in text\u0022 id=\u0022ref-18\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.18\u0022 data-doi=\u002210.1006\/pmed.2000.0643\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFeldman\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohannes\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDerby\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECA\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EPrev Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2000\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E30\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E328\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E38\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1006\/pmed.2000.0643\u0022\u003Edoi:10.1006\/pmed.2000.0643\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DPreventive%2Bmedicine%26rft.stitle%253DPrev%2BMed%26rft.aulast%253DFeldman%26rft.auinit1%253DH.%2BA.%26rft.volume%253D30%26rft.issue%253D4%26rft.spage%253D328%26rft.epage%253D338%26rft.atitle%253DErectile%2Bdysfunction%2Band%2Bcoronary%2Brisk%2Bfactors%253A%2Bprospective%2Bresults%2Bfrom%2Bthe%2BMassachusetts%2Bmale%2Baging%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1006%252Fpmed.2000.0643%26rft_id%253Dinfo%253Apmid%252F10731462%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1006\/pmed.2000.0643\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10731462\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000086370100011\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-19-1\u0022 title=\u0022View reference 19 in text\u0022 id=\u0022ref-19\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.19\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVlachopoulos\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIoakeimidis\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETerentes-Printzios\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EThe triad: erectile dysfunction-endothelial dysfunction-cardiovascular disease Curr Pharm Des\u003C\/span\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2008\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E14\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E3700\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E14\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-20-1\u0022 title=\u0022View reference 20 in text\u0022 id=\u0022ref-20\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.20\u0022 data-doi=\u002210.1038\/ncpcardio0861\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWatts\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChew\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EStuckey\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBG\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EThe erectile-endothelial dysfunction nexus: new opportunities for cardiovascular risk prevention\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ENat Clin Pract Cardiovasc Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E4\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E263\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E73\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1038\/ncpcardio0861\u0022\u003Edoi:10.1038\/ncpcardio0861\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.stitle%253DNat%2BClin%2BPract%2BCardiovasc%2BMed%26rft.aulast%253DWatts%26rft.auinit1%253DG.%2BF.%26rft.volume%253D4%26rft.issue%253D5%26rft.spage%253D263%26rft.epage%253D273%26rft.atitle%253DThe%2Berectile-endothelial%2Bdysfunction%2Bnexus%253A%2Bnew%2Bopportunities%2Bfor%2Bcardiovascular%2Brisk%2Bprevention.%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fncpcardio0861%26rft_id%253Dinfo%253Apmid%252F17457350%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1038\/ncpcardio0861\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17457350\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-21-1\u0022 title=\u0022View reference 21 in text\u0022 id=\u0022ref-21\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.21\u0022 data-doi=\u002210.1016\/S0302-2838(03)00305-1\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMontorsi\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBriganti\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESalonia\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2003\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E44\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E360\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E5\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/S0302-2838(03)00305-1\u0022\u003Edoi:10.1016\/S0302-2838(03)00305-1\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2Burology%26rft.stitle%253DEur%2BUrol%26rft.aulast%253DMontorsi%26rft.auinit1%253DF.%26rft.volume%253D44%26rft.issue%253D3%26rft.spage%253D360%26rft.epage%253D364%26rft.atitle%253DErectile%2Bdysfunction%2Bprevalence%252C%2Btime%2Bof%2Bonset%2Band%2Bassociation%2Bwith%2Brisk%2Bfactors%2Bin%2B300%2Bconsecutive%2Bpatients%2Bwith%2Bacute%2Bchest%2Bpain%2Band%2Bangiographically%2Bdocumented%2Bcoronary%2Bartery%2Bdisease.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0302-2838%252803%252900305-1%26rft_id%253Dinfo%253Apmid%252F12932937%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/S0302-2838(03)00305-1\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=12932937\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000185462700016\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-22-1\u0022 title=\u0022View reference 22 in text\u0022 id=\u0022ref-22\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.22\u0022 data-doi=\u002210.1016\/j.eururo.2005.08.002\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVlachopoulos\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERokkas\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIoakeimidis\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPrevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: a prospective angiographic study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E48\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E996\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E1003\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.eururo.2005.08.002\u0022\u003Edoi:10.1016\/j.eururo.2005.08.002\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2Burology%26rft.stitle%253DEur%2BUrol%26rft.aulast%253DVlachopoulos%26rft.auinit1%253DC.%26rft.volume%253D48%26rft.issue%253D6%26rft.spage%253D996%26rft.epage%253D1002%26rft.atitle%253DPrevalence%2Bof%2Basymptomatic%2Bcoronary%2Bartery%2Bdisease%2Bin%2Bmen%2Bwith%2Bvasculogenic%2Berectile%2Bdysfunction%253A%2Ba%2Bprospective%2Bangiographic%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.eururo.2005.08.002%26rft_id%253Dinfo%253Apmid%252F16174548%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/j.eururo.2005.08.002\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=16174548\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000233662600019\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-23-1\u0022 title=\u0022View reference 23 in text\u0022 id=\u0022ref-23\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.23\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMulhall\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETeloken\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBarnas\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EVasculogenic erectile dysfunction is a predictor of abnormal stress echocardiography\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E6\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E820\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E5\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1743-6109.2008.01087.x\u0022\u003Edoi:10.1111\/j.1743-6109.2008.01087.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.stitle%253DJ%2BSex%2BMed%26rft.aulast%253DMulhall%26rft.auinit1%253DJ.%26rft.volume%253D6%26rft.issue%253D3%26rft.spage%253D820%26rft.epage%253D825%26rft.atitle%253DVasculogenic%2Berectile%2Bdysfunction%2Bis%2Ba%2Bpredictor%2Bof%2Babnormal%2Bstress%2Bechocardiography.%26rft_id%253Dinfo%253Apmid%252F19170867%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19170867\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-24-1\u0022 title=\u0022View reference 24 in text\u0022 id=\u0022ref-24\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.24\u0022 data-doi=\u002210.1111\/j.1742-1241.2007.01629.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodges\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKirby\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESolanki\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EThe temporal relationship between erectile dysfunction and cardiovascular disease\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EInt J Clin Pract\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E61\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2019\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E25\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1742-1241.2007.01629.x\u0022\u003Edoi:10.1111\/j.1742-1241.2007.01629.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DInternational%2Bjournal%2Bof%2Bclinical%2Bpractice%26rft.stitle%253DInt%2BJ%2BClin%2BPract%26rft.aulast%253DHodges%26rft.auinit1%253DL.%2BD.%26rft.volume%253D61%26rft.issue%253D12%26rft.spage%253D2019%26rft.epage%253D2025%26rft.atitle%253DThe%2Btemporal%2Brelationship%2Bbetween%2Berectile%2Bdysfunction%2Band%2Bcardiovascular%2Bdisease.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1742-1241.2007.01629.x%26rft_id%253Dinfo%253Apmid%252F17997808%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1111\/j.1742-1241.2007.01629.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17997808\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000250796800014\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-25-1\u0022 title=\u0022View reference 25 in text\u0022 id=\u0022ref-25\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.25\u0022 data-doi=\u002210.4065\/84.2.108\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EInman\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESauver\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJacobson\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EA population-based, longitudinal study of erectile dysfunction and future coronary artery disease\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EMayo Clin Proc\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E84\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E108\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E13\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.4065\/84.2.108\u0022\u003Edoi:10.4065\/84.2.108\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DMayo%2BClinic%2BProceedings%26rft.stitle%253DMayo%2BClin%2BProc.%26rft.aulast%253DInman%26rft.auinit1%253DB.%2BA.%26rft.volume%253D84%26rft.issue%253D2%26rft.spage%253D108%26rft.epage%253D113%26rft.atitle%253DA%2BPopulation-Based%252C%2BLongitudinal%2BStudy%2Bof%2BErectile%2BDysfunction%2Band%2BFuture%2BCoronary%2BArtery%2BDisease%26rft_id%253Dinfo%253Adoi%252F10.4065%252F84.2.108%26rft_id%253Dinfo%253Apmid%252F19181643%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.4065\/84.2.108\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19181643\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000262992500003\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-26-1\u0022 title=\u0022View reference 26 in text\u0022 id=\u0022ref-26\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.26\u0022 data-doi=\u002210.1016\/j.eururo.2005.05.014\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPonholzer\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETemml\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EObermayr\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EIs erectile dysfunction an indicator for increased risk of coronary heart disease and stroke?\u003C\/span\u003E \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E48\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E512\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E8\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.eururo.2005.05.014\u0022\u003Edoi:10.1016\/j.eururo.2005.05.014\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2Burology%26rft.stitle%253DEur%2BUrol%26rft.aulast%253DPonholzer%26rft.auinit1%253DA.%26rft.volume%253D48%26rft.issue%253D3%26rft.spage%253D512%26rft.epage%253D518%26rft.atitle%253DIs%2Berectile%2Bdysfunction%2Ban%2Bindicator%2Bfor%2Bincreased%2Brisk%2Bof%2Bcoronary%2Bheart%2Bdisease%2Band%2Bstroke%253F%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.eururo.2005.05.014%26rft_id%253Dinfo%253Apmid%252F15998563%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/j.eururo.2005.05.014\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=15998563\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000231724300022\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-27-1\u0022 title=\u0022View reference 27 in text\u0022 id=\u0022ref-27\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.27\u0022 data-doi=\u002210.1001\/jama.294.23.2996\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EThompson\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EIM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETangen\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGoodman\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction and subsequent cardiovascular disease\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJAMA\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E294\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2996\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E3002\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1001\/jama.294.23.2996\u0022\u003Edoi:10.1001\/jama.294.23.2996\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.aulast%253DThompson%26rft.auinit1%253DI.%2BM.%26rft.volume%253D294%26rft.issue%253D23%26rft.spage%253D2996%26rft.epage%253D3002%26rft.atitle%253DErectile%2BDysfunction%2Band%2BSubsequent%2BCardiovascular%2BDisease%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.294.23.2996%26rft_id%253Dinfo%253Apmid%252F16414947%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1001\/jama.294.23.2996\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=16414947\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000234087700026\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-28-1\u0022 title=\u0022View reference 28 in text\u0022 id=\u0022ref-28\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.28\u0022 data-doi=\u002210.1371\/journal.pmed.1001372\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBanks\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJoshy\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAbhayaratna\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWP\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction severity as a risk marker for cardiovascular disease hospitalisation and all-cause mortality: a prospective cohort study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EPLoS Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E10\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003Ee1001372\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1371\/journal.pmed.1001372\u0022\u003Edoi:10.1371\/journal.pmed.1001372\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DPLoS%2BMed%26rft.volume%253D10%26rft.spage%253De1001372%26rft_id%253Dinfo%253Adoi%252F10.1371%252Fjournal.pmed.1001372%26rft_id%253Dinfo%253Apmid%252F23382654%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1371\/journal.pmed.1001372\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23382654\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-29-1\u0022 title=\u0022View reference 29 in text\u0022 id=\u0022ref-29\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.29\u0022 data-doi=\u002210.1111\/j.1743-6109.2010.01778.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELewis\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFugl-Meyer\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECorona\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EDefinitions\/epidemiology\/risk factors for sexual dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E7\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1598\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E607\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1743-6109.2010.01778.x\u0022\u003Edoi:10.1111\/j.1743-6109.2010.01778.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.stitle%253DJ%2BSex%2BMed%26rft.aulast%253DLewis%26rft.auinit1%253DR.%2BW.%26rft.volume%253D7%26rft.issue%253D4%2BPt%2B2%26rft.spage%253D1598%26rft.epage%253D1607%26rft.atitle%253DDefinitions%252Fepidemiology%252Frisk%2Bfactors%2Bfor%2Bsexual%2Bdysfunction.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1743-6109.2010.01778.x%26rft_id%253Dinfo%253Apmid%252F20388160%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1111\/j.1743-6109.2010.01778.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20388160\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-30-1\u0022 title=\u0022View reference 30 in text\u0022 id=\u0022ref-30\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.30\u0022 data-doi=\u002210.1007\/s11255-007-9293-8\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYaman\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EO\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGulpinar\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EO\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHasan\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction may predict coronary artery disease: relationship between coronary artery calcium scoring and erectile dysfunction severity\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EInt Urol Nephrol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2008\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E40\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E117\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E23\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1007\/s11255-007-9293-8\u0022\u003Edoi:10.1007\/s11255-007-9293-8\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DInternational%2Burology%2Band%2Bnephrology%26rft.stitle%253DInt%2BUrol%2BNephrol%26rft.aulast%253DYaman%26rft.auinit1%253DO.%26rft.volume%253D40%26rft.issue%253D1%26rft.spage%253D117%26rft.epage%253D123%26rft.atitle%253DErectile%2Bdysfunction%2Bmay%2Bpredict%2Bcoronary%2Bartery%2Bdisease%253A%2Brelationship%2Bbetween%2Bcoronary%2Bartery%2Bcalcium%2Bscoring%2Band%2Berectile%2Bdysfunction%2Bseverity.%26rft_id%253Dinfo%253Adoi%252F10.1007%252Fs11255-007-9293-8%26rft_id%253Dinfo%253Apmid%252F17975736%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1007\/s11255-007-9293-8\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17975736\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-31-1\u0022 title=\u0022View reference 31 in text\u0022 id=\u0022ref-31\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.31\u0022 data-doi=\u002210.1093\/eurheartj\/ehl142\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMontorsi\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERavagnani\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGalli\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAssociation between erectile dysfunction and coronary artery disease. role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Heart J\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2006\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E27\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2632\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E9\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1093\/eurheartj\/ehl142\u0022\u003Edoi:10.1093\/eurheartj\/ehl142\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2BHeart%2BJournal%26rft.stitle%253DEur%2BHeart%2BJ%26rft.volume%253D27%26rft.issue%253D22%26rft.spage%253D2632%26rft.epage%253D2639%26rft.atitle%253DAssociation%2Bbetween%2Berectile%2Bdysfunction%2Band%2Bcoronary%2Bartery%2Bdisease.%2BRole%2Bof%2Bcoronary%2Bclinical%2Bpresentation%2Band%2Bextent%2Bof%2Bcoronary%2Bvessels%2Binvolvement%253A%2Bthe%2BCOBRA%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1093%252Feurheartj%252Fehl142%26rft_id%253Dinfo%253Apmid%252F16854949%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1093\/eurheartj\/ehl142\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=16854949\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-31-2\u0022 title=\u0022View reference 32 in text\u0022 id=\u0022ref-32\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.32\u0022 data-doi=\u002210.1016\/j.eururo.2006.07.015\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMontorsi\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERavagnani\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGalli\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAssociation between erectile dysfunction and coronary artery disease:matching the right target with the right test in the right patient\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2006\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E50\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E721\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E31\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.eururo.2006.07.015\u0022\u003Edoi:10.1016\/j.eururo.2006.07.015\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2Burology%26rft.stitle%253DEur%2BUrol%26rft.aulast%253DMontorsi%26rft.auinit1%253DP.%26rft.volume%253D50%26rft.issue%253D4%26rft.spage%253D721%26rft.epage%253D731%26rft.atitle%253DAssociation%2Bbetween%2Berectile%2Bdysfunction%2Band%2Bcoronary%2Bartery%2Bdisease%253A%2BMatching%2Bthe%2Bright%2Btarget%2Bwith%2Bthe%2Bright%2Btest%2Bin%2Bthe%2Bright%2Bpatient.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.eururo.2006.07.015%26rft_id%253Dinfo%253Apmid%252F16901623%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/j.eururo.2006.07.015\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=16901623\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-33-1\u0022 title=\u0022View reference 33 in text\u0022 id=\u0022ref-33\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.33\u0022 data-doi=\u002210.2164\/jandrol.107.004630\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYassin\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESaad\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ETestosterone and erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Androl\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2008\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E29\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E593\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E604\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2164\/jandrol.107.004630\u0022\u003Edoi:10.2164\/jandrol.107.004630\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJ%2BAndrol%26rft_id%253Dinfo%253Adoi%252F10.2164%252Fjandrol.107.004630%26rft_id%253Dinfo%253Apmid%252F18641415%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.2164\/jandrol.107.004630\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=18641415\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000260399300001\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-34-1\u0022 title=\u0022View reference 34 in text\u0022 id=\u0022ref-34\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.34\u0022 data-doi=\u002210.1111\/j.1743-6109.2008.01159.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKhera\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAndrogens and erectile function: a case for early androgen use in postprostatectomy hypogonadal men\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E6\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E234\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E8\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1743-6109.2008.01159.x\u0022\u003Edoi:10.1111\/j.1743-6109.2008.01159.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJ%2BSex%2BMed%26rft.volume%253D6%26rft.spage%253D234%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1743-6109.2008.01159.x%26rft_id%253Dinfo%253Apmid%252F19207279%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1111\/j.1743-6109.2008.01159.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19207279\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000266552200006\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-35-1\u0022 title=\u0022View reference 35 in text\u0022 id=\u0022ref-35\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.35\u0022 data-doi=\u002210.1046\/j.1365-2265.2000.01118.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAversa\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIsidori\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDe Martino\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMU\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAndrogens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClin Endocrinol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2000\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E53\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E517\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E22\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1046\/j.1365-2265.2000.01118.x\u0022\u003Edoi:10.1046\/j.1365-2265.2000.01118.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DClinical%2Bendocrinology%26rft.stitle%253DClin%2BEndocrinol%2B%2528Oxf%2529%26rft.aulast%253DAversa%26rft.auinit1%253DA.%26rft.volume%253D53%26rft.issue%253D4%26rft.spage%253D517%26rft.epage%253D522%26rft.atitle%253DAndrogens%2Band%2Bpenile%2Berection%253A%2Bevidence%2Bfor%2Ba%2Bdirect%2Brelationship%2Bbetween%2Bfree%2Btestosterone%2Band%2Bcavernous%2Bvasodilation%2Bin%2Bmen%2Bwith%2Berectile%2Bdysfunction.%26rft_id%253Dinfo%253Adoi%252F10.1046%252Fj.1365-2265.2000.01118.x%26rft_id%253Dinfo%253Apmid%252F11012578%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1046\/j.1365-2265.2000.01118.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=11012578\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-36-1\u0022 title=\u0022View reference 36 in text\u0022 id=\u0022ref-36\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.36\u0022 data-doi=\u002210.1016\/j.eururo.2006.01.028\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWespes\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAmar\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatzichristou\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EEAU guidelines on erectile dysfunction: an update\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2006\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E49\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E806\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E15\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.eururo.2006.01.028\u0022\u003Edoi:10.1016\/j.eururo.2006.01.028\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DEuropean%2Burology%26rft.stitle%253DEur%2BUrol%26rft.aulast%253DWespes%26rft.auinit1%253DE.%26rft.volume%253D49%26rft.issue%253D5%26rft.spage%253D806%26rft.epage%253D815%26rft.atitle%253DEAU%2BGuidelines%2Bon%2Berectile%2Bdysfunction%253A%2Ban%2Bupdate.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.eururo.2006.01.028%26rft_id%253Dinfo%253Apmid%252F16530932%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/j.eururo.2006.01.028\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=16530932\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000237127100010\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-37-1\u0022 title=\u0022View reference 37 in text\u0022 id=\u0022ref-37\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-web\u0022 id=\u0022cit-93.1105.679.37\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Ccite\u003E\u003Cspan class=\u0022cit-auth cit-collab\u0022\u003EU.S. Food and Drug Administration\u003C\/span\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EFDA Drug Safety Communication: fda cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm436259.htm\u0022\u003Ewww.fda.gov\/Drugs\/DrugSafety\/ucm436259.htm\u003C\/a\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-38-1\u0022 title=\u0022View reference 38 in text\u0022 id=\u0022ref-38\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.38\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBassil\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAlkaade\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMorley\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EThe benefits and risks of testosterone replacement therapy: a review\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ETher Clin Risk Manag\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E5\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E427\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E48\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.stitle%253DTher%2BClin%2BRisk%2BManag%26rft.aulast%253DBassil%26rft.auinit1%253DN.%26rft.volume%253D5%26rft.issue%253D3%26rft.spage%253D427%26rft.epage%253D448%26rft.atitle%253DThe%2Bbenefits%2Band%2Brisks%2Bof%2Btestosterone%2Breplacement%2Btherapy%253A%2Ba%2Breview.%26rft_id%253Dinfo%253Apmid%252F19707253%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19707253\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-39-1\u0022 title=\u0022View reference 39 in text\u0022 id=\u0022ref-39\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.39\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ES\u00f8e\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ES\u00f8e\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGluud\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ELiver pathology associated with the use of anabolic-androgenic steroids\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ELiver\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1992\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E12\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E73\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E9\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1600-0676.1992.tb00560.x\u0022\u003Edoi:10.1111\/j.1600-0676.1992.tb00560.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DLiver%26rft.stitle%253DLiver%26rft.aulast%253DS%25C3%25B8e%26rft.auinit1%253DK.%2BL.%26rft.volume%253D12%26rft.issue%253D2%26rft.spage%253D73%26rft.epage%253D79%26rft.atitle%253DLiver%2Bpathology%2Bassociated%2Bwith%2Bthe%2Buse%2Bof%2Banabolic-androgenic%2Bsteroids.%26rft_id%253Dinfo%253Apmid%252F1535676%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=1535676\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=A1992HW32500005\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-40-1\u0022 title=\u0022View reference 40 in text\u0022 id=\u0022ref-40\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.40\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERandrup\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBaum\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFeibus\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EErectile dysfunction and cardiovascular disease\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EPostgrad Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2015\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E127\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E166\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E72\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1080\/00325481.2015.992722\u0022\u003Edoi:10.1080\/00325481.2015.992722\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DPostgrad%2BMed%26rft.volume%253D127%26rft.spage%253D166%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-41-1\u0022 title=\u0022View reference 41 in text\u0022 id=\u0022ref-41\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.41\u0022 data-doi=\u002210.1111\/j.1743-6109.2009.01301.x\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWrishko\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESorsaburu\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWong\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESafety, efficacy, and pharmacokinetic overview of low-dose daily administration of tadalafil\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E6\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2039\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E48\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\/j.1743-6109.2009.01301.x\u0022\u003Edoi:10.1111\/j.1743-6109.2009.01301.x\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.stitle%253DJ%2BSex%2BMed%26rft.aulast%253DWrishko%26rft.auinit1%253DR.%26rft.volume%253D6%26rft.issue%253D7%26rft.spage%253D2039%26rft.epage%253D2048%26rft.atitle%253DSafety%252C%2Befficacy%252C%2Band%2Bpharmacokinetic%2Boverview%2Bof%2Blow-dose%2Bdaily%2Badministration%2Bof%2Btadalafil.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1743-6109.2009.01301.x%26rft_id%253Dinfo%253Apmid%252F19453893%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1111\/j.1743-6109.2009.01301.x\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19453893\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-42-1\u0022 title=\u0022View reference 42 in text\u0022 id=\u0022ref-42\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.42\u0022 data-doi=\u002210.1097\/01.ju.0000125198.32936.38\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESeftel\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESun\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESwindle\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EThe prevalence of hypertension, Hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2004\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E171\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2341\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E5\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1097\/01.ju.0000125198.32936.38\u0022\u003Edoi:10.1097\/01.ju.0000125198.32936.38\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DThe%2BJournal%2Bof%2Burology%26rft.stitle%253DJ%2BUrol%26rft.aulast%253DSeftel%26rft.auinit1%253DA.%2BD.%26rft.volume%253D171%26rft.issue%253D6%2BPt%2B1%26rft.spage%253D2341%26rft.epage%253D2345%26rft.atitle%253DThe%2Bprevalence%2Bof%2Bhypertension%252C%2Bhyperlipidemia%252C%2Bdiabetes%2Bmellitus%2Band%2Bdepression%2Bin%2Bmen%2Bwith%2Berectile%2Bdysfunction.%26rft_id%253Dinfo%253Adoi%252F10.1097%252F01.ju.0000125198.32936.38%26rft_id%253Dinfo%253Apmid%252F15126817%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1097\/01.ju.0000125198.32936.38\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=15126817\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000221510300050\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-43-1\u0022 title=\u0022View reference 43 in text\u0022 id=\u0022ref-43\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-web\u0022 id=\u0022cit-93.1105.679.43\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Ccite\u003E\u003Cspan class=\u0022cit-auth cit-collab\u0022\u003EAmerican association of sexuality educators,counselors and therapists\u003C\/span\u003E \u003Ca href=\u0022https:\/\/www.aasect.org\/certification\u0022\u003Ehttps:\/\/www.aasect.org\/certification\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-44-1\u0022 title=\u0022View reference 44 in text\u0022 id=\u0022ref-44\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-book\u0022 id=\u0022cit-93.1105.679.44\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKaplan\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-source\u0022\u003EBasic principles of sex therapy, Plenum Publishing\u003C\/span\u003E, \u003Cspan class=\u0022cit-pub-date\u0022\u003E1980\u003C\/span\u003E.\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-45-1\u0022 title=\u0022View reference 45 in text\u0022 id=\u0022ref-45\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.45\u0022 data-doi=\u002210.1016\/0090-4295(93)90620-P\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERandrup\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWilson\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMobley\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003Cspan class=\u0022cit-etal\u0022\u003Eet al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EClinical experience with Mentor Alpha I inflatable penile prosthesis. Report on 333 cases\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EUrology\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E1993\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E42\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E305\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E8\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/0090-4295(93)90620-P\u0022\u003Edoi:10.1016\/0090-4295(93)90620-P\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DUrology%26rft.stitle%253DUrology%26rft.aulast%253DRandrup%26rft.auinit1%253DE.%26rft.volume%253D42%26rft.issue%253D3%26rft.spage%253D305%26rft.epage%253D308%26rft.atitle%253DClinical%2Bexperience%2Bwith%2BMentor%2BAlpha%2BI%2Binflatable%2Bpenile%2Bprosthesis.%2BReport%2Bon%2B333%2Bcases.%26rft_id%253Dinfo%253Adoi%252F10.1016%252F0090-4295%252893%252990620-P%26rft_id%253Dinfo%253Apmid%252F8379030%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/0090-4295(93)90620-P\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=8379030\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=A1993LX67200012\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-46-1\u0022 title=\u0022View reference 46 in text\u0022 id=\u0022ref-46\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.46\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKhera\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAlbersen\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMulhall\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJP\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EMesenchymal stem cell therapy for the treatment of erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2015\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E12\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1105\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E6\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\https://pmj.bmj.com/jsm.12871\u0022\u003Edoi:10.1111\https://pmj.bmj.com/jsm.12871\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJ%2BSex%2BMed%26rft.volume%253D12%26rft.spage%253D1105%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-47-1\u0022 title=\u0022View reference 47 in text\u0022 id=\u0022ref-47\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.47\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFrey\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ES\u00f8nksen\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFode\u003C\/span\u003E \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ELow-intensity extracorporeal shockwave therapy in the treatment of postprostatectomy erectile dysfunction: a pilot study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EScand J Urol\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2016\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E50\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E5\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.3109\/21681805.2015.1100675\u0022\u003Edoi:10.3109\/21681805.2015.1100675\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DScand%2BJ%2BUrol%26rft.volume%253D50%26rft.spage%253D1%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-48-1\u0022 title=\u0022View reference 48 in text\u0022 id=\u0022ref-48\u0022\u003E\u21b5\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-93.1105.679.48\u0022 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al\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ENitric oxide-releasing polymeric microspheres improve diabetes-related erectile dysfunction\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Sex Med\u003C\/abbr\u003E \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E10\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1915\u003C\/span\u003E\u2013\u003Cspan class=\u0022cit-lpage\u0022\u003E25\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1111\https://pmj.bmj.com/jsm.12216\u0022\u003Edoi:10.1111\https://pmj.bmj.com/jsm.12216\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022{openurl}?query=rft.jtitle%253DJ%2BSex%2BMed%26rft.volume%253D10%26rft.spage%253D1915%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjsm.12216%26rft_id%253Dinfo%253Apmid%252F23751157%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1111\https://pmj.bmj.com/jsm.12216\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23751157\u0026amp;link_type=MED\u0026amp;atom=%2Fpostgradmedj%2F93%2F1105%2F679.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022https:\/\/pmj.bmj.com\/content\/93\/1105\/679.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Abstract\u003C\/a\u003E\u003C\/div\u003E \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup footnotes\u0022 \u003E\n \n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022section fn-group\u0022 id=\u0022fn-group-1\u0022\u003E\u003Ch2\u003EFootnotes\u003C\/h2\u003E\u003Cul\u003E\u003Cli class=\u0022fn-other\u0022 id=\u0022fn-1\u0022\u003E\u003Cp id=\u0022p-79\u0022\u003E\u003Cspan class=\u0022fn-label\u0022\u003EContributors\u003C\/span\u003E DFM and NB wrote the majority of the manuscript. MK wrote the section on testosterone and made review comments and approved the final manuscript along with the attached figure.\u003C\/p\u003E\u003C\/li\u003E\u003Cli class=\u0022fn-conflict\u0022 id=\u0022fn-2\u0022\u003E\u003Cp id=\u0022p-80\u0022\u003E\u003Cspan class=\u0022fn-label\u0022\u003ECompeting interests\u003C\/span\u003E None declared.\u003C\/p\u003E\u003C\/li\u003E\u003Cli class=\u0022fn-other\u0022 id=\u0022fn-3\u0022\u003E\u003Cp id=\u0022p-81\u0022\u003E\u003Cspan class=\u0022fn-label\u0022\u003EProvenance and peer review\u003C\/span\u003E Not commissioned; externally peer reviewed.\u003C\/p\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E \u003C\/div\u003E\n\n \n \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2\u0022 \u003E\n \n \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n \n \n \u003Cdiv class=\u0022pane-content\u0022\u003E\n \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. 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